Induction Agents for Endotracheal Intubation in Severe Sepsis and Septic Shock
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Etomidate, sepsis, and adrenal function: not as bad as we thought?
The choice of induction agent for endotracheal intubation can have significant downstream effects, especially in critically ill patients. In a retrospective study, Ray and McKeown found that the choice of induction agent had no significant effect on use of vasoactive medications, corticosteroids, or mortality. Given the heated debate regarding corticosteroids in septic shock and the role that e...
متن کاملEtomidate for intubation of patients who have sepsis or septic shock - where do we go from here?
Etomidate is an intravenous induction agent that is associated with hemodynamic stability during intubation. The agent is therefore attractive for use in critically ill patients who have a high risk of hemodynamic instability during this procedure. However, etomidate causes adrenal suppression, which itself has been associated with increased mortality in critically ill patients. The ongoing deb...
متن کاملSingle-dose etomidate is not associated with increased mortality in ICU patients with sepsis: analysis of a large electronic ICU database.
OBJECTIVE Retrospective analyses of several trials suggest etomidate may be unsafe for intubation in patients with sepsis. We evaluated the association of etomidate and mortality in a large cohort of septic patients to determine if single-dose etomidate was associated with increased in-hospital mortality. DESIGN AND SETTING Retrospective cohort study at the Philips eICU Research Institute ICU...
متن کاملبررسی موارد سپسیس و شوک سپتیک در بخش مراقبت های ویژه بیمارستان مرکز طبی کودکان
Sepsis is the systemic response to severe infection in critically ill patients. Sepsis, septic syndrome & septic shock represent the increasingly severe stages of the same disease. Despite the remarkable improvements in outcome, sepsis & septic shock remain an important cause of morbidity & mortality in children. This is a retrospective study among the patients who were admitted in the pediatri...
متن کاملEtomidate Should be Used Carefully for Emergent Endotracheal Intubation in Patients with Septic Shock
Etomidate and midazolam are the most popular drugs among the induction agents for emergent endotracheal intubation. The purpose of this study was to compare the incidence of adrenal insufficiency and mortality between the septic shock patients who received etomidate (ETM group) and those who received midazolam (MDZ group). Between November 2004 and September 2006, 65 patients were analyzed in t...
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تاریخ انتشار 2017